Demi Lovato & Dua Lipa Headline MISTR’s PrEP Day Celebration
West Hollywood shimmered with celebrity star power and passionate advocacy on Thursday, October 9, 2025, as Demi Lovato and Dua Lipa headlined MISTR’s inaugural National PrEP Day celebration. Hosted at the iconic Abbey, the event served as a vibrant platform to raise crucial awareness about PrEP (pre-exposure prophylaxis), a life-saving medication in the fight against HIV. The evening combined electrifying musical performances with powerful calls for accessible healthcare, uniting a constellation of stars in support of a vital cause.
The highly anticipated gathering marked the culmination of a nationwide 10-day campaign by MISTR, aiming to get 10,000 new individuals on PrEP. From the moment attendees stepped onto the blue carpet to the final beats dropped by the night’s celebrity DJs and performers, the atmosphere was charged with a blend of celebration, education, and unwavering commitment to sexual health.
A Night of Music, Advocacy, and Star Power in West Hollywood
Demi Lovato’s Powerful Message and New Music Debut
The night reached a fever pitch when Demi Lovato, known for her powerful vocals and fierce advocacy, took to the DJ booth alongside superstar producer Diplo. In a moment that perfectly encapsulated the spirit of the event, Lovato premiered her newest single, “Kiss,” which officially dropped the following day, October 10, accompanied by a sexy new music video. The crowd erupted as the track filled The Abbey, but it was Lovato’s heartfelt message that truly resonated.
Addressing the enthusiastic audience, Lovato declared, “Let’s make out, have fun and be safe with MISTR!” Her words were not just a catchy tagline for her new song but a direct, empowering statement in line with the event’s core mission. It was a reminder that embracing one’s sexuality can and should go hand-in-hand with prioritizing health and safety. Lovato’s presence underscored her long-standing commitment to authentic self-expression and well-being, now extending her influential voice to sexual health awareness.
The debut of “Kiss” at such a significant event further cemented Lovato’s artistic evolution, blending her musical prowess with her impactful activism. Her ability to command the stage and inspire her fans to engage with important social issues positions her as a pivotal figure in contemporary pop culture.
Dua Lipa Electrifies The Abbey Stage
Adding another layer of global superstar wattage to the evening, Dua Lipa delivered a dazzling performance that left the crowd spellbound. Fresh off a successful four-night tour stop in Los Angeles, the pop sensation brought her signature energy and undeniable stage presence to The Abbey. Her setlist was a journey through her hit-laden discography, with fans singing and dancing along to anthems like “New Rules,” “Don’t Start Now,” and her latest smash, “Houdini.”
Lipa’s performance was more than just entertainment; it was a vibrant testament to the power of music to bring people together in celebration and solidarity. Her effortless charisma and infectious enthusiasm amplified the festive atmosphere, proving why she remains one of the most dynamic performers in music today. Her decision to perform at National PrEP Day highlighted the broad appeal and critical importance of the initiative, drawing diverse audiences to a cause that affects everyone.
A Galaxy of Stars United for a Cause
The energy of the night was further amplified by a star-studded guest list that turned The Abbey into a nexus of celebrity support. Emceed by the charismatic Bob the Drag Queen, the event saw a diverse array of prominent figures from music, television, and pop culture converge for a shared purpose. Among the notable attendees were the fiercely independent Cardi B, multi-talented Tamar Braxton, groundbreaking pop artist Kim Petras, acclaimed actor Matt Bomer, reality TV icons NeNe Leakes and Cynthia Bailey, rising music sensation Omar Apollo, “RuPaul’s Drag Race” winner Shea Couleé, and television personality Colton Underwood.
The collective presence of such influential individuals underscored the widespread recognition of PrEP’s importance and the urgency of MISTR’s campaign. Each celebrity, by their attendance, lent their powerful platforms to the conversation surrounding sexual health, helping to destigmatize discussions and encourage proactive prevention. It was a clear demonstration of how cultural leaders can unite to champion public health initiatives, fostering a sense of community and shared responsibility.
Understanding PrEP: A Critical Step in HIV Prevention
MISTR’s Pioneering Campaign and Vision
Beyond the celebrity glitz and electrifying performances, the core message of the National PrEP Day celebration remained firmly rooted in public health education. PrEP, or pre-exposure prophylaxis, is a revolutionary medication that, when taken as a daily pill or a twice-yearly injection, has been scientifically proven to reduce the risk of HIV transmission by an astounding 99 percent. This highly effective tool represents a monumental leap forward in HIV prevention, offering individuals greater control over their sexual health and significantly curbing the spread of the virus.
MISTR’s initiative was not just about awareness; it was about action. The 10-day national campaign preceding the event aimed to enroll 10,000 new people onto PrEP by October 10. This ambitious goal reflects MISTR’s commitment to making PrEP accessible and widely understood. Tristan Schukraft, founder and CEO of MISTR, articulated the organization’s powerful vision, telling PEOPLE, “We can end HIV. We have the tools. Being on PrEP is all about taking control of your own sexual health, just like the birth control pill was when it came out for women. By taking PrEP you’re actually doing your part to end the epidemic.” His words highlighted PrEP as not merely a medication, but a tool for empowerment and collective impact.
Demi Lovato’s Passionate Advocacy for Accessible Healthcare
Demi Lovato further elaborated on the profound significance of the event during a blue carpet interview with Getty, emphasizing her reasons for being a vocal supporter. “MISTR is doing incredible work for the community. Everyone’s health care should be accessible and affordable, especially when it comes to life-saving medication like PrEP,” she stated, echoing a sentiment widely shared among advocates for health equity.
Lovato continued, highlighting the importance of open dialogue: “It’s so important to talk about sexual health so that we’re looking out for one another, and the queer community has done an incredible job at that.” Her acknowledgment of the queer community’s leadership in sexual health discourse underscored the event’s intersectional message and the vital role of specific communities in pioneering such conversations. She concluded her remarks by commending the event’s spirit, adding, “It’s so inspiring to see people educate, entertain and uplift one another. It’s what we all need to be doing right now.” Her powerful words served as a call to action, urging everyone to engage in dialogue, support, and collective upliftment.
Lovato’s Evolving Journey: Music, Marriage, and Meaningful Messages
A New Chapter: Married Life and Lighter Tones
The National PrEP Day celebration offered a glimpse into Demi Lovato’s flourishing personal and professional life. The singer, who married singer-songwriter Jordan “Jutes” Lutes in a beautiful ceremony in May, has openly spoken about the transformative impact of her marriage on her artistry. Her upcoming album, “It’s Not That Deep,” set for release on October 24, is anticipated to showcase a lighter, more joyful side of the artist.
Prior to “Kiss,” Lovato had already released two other singles from the album, “Fast” and “Here All Night,” giving fans a taste of her evolving sound. This new musical chapter, marked by a reported shift away from “huge emotional ballads” towards a “lighter tone of my life,” aligns perfectly with her recent personal happiness and stable relationship. Her choice to debut “Kiss” at an event promoting health and safety further illustrates her commitment to living authentically and transparently, sharing both her vulnerabilities and her strengths with her dedicated fanbase.
Beyond the Stage: Lovato’s Ongoing Commitment to Wellness
Lovato’s appearance at MISTR’s National PrEP Day event is a testament to her consistent dedication to various facets of wellness. Throughout her career, she has been a vocal proponent of mental health awareness, body positivity, and sobriety. Her advocacy for PrEP and accessible healthcare now broadens this commitment, demonstrating a holistic approach to well-being that resonates deeply with her audience.
By lending her voice and platform to such a critical public health initiative, Lovato reinforces her image as an artist who uses her influence for good. Her journey of self-discovery, recovery, and empowerment continues to inspire millions, and her active participation in events like National PrEP Day serves as a powerful reminder that celebrity can be a force for positive social change, fostering a world where everyone can live their healthiest, most authentic lives.
Frequently Asked Questions
What was the purpose of MISTR’s National PrEP Day celebration?
It aimed to raise crucial awareness about PrEP (pre-exposure prophylaxis) and enroll 10,000 new individuals onto PrEP.
Who were the headliners for MISTR’s first-ever National PrEP Day celebration?
Demi Lovato and Dua Lipa headlined the event in West Hollywood.
What is PrEP and how effective is it?
PrEP (pre-exposure prophylaxis) is a medication that, when taken daily or twice-yearly, reduces the risk of HIV transmission by 99 percent.
What new single did Demi Lovato premiere at the event?
Demi Lovato premiered her newest single, “Kiss,” which officially dropped the following day.
Who is the founder and CEO of MISTR?
Tristan Schukraft is the founder and CEO of MISTR.
